Mapping of myogenin transcription during embryogenesis using transgenes linked to the myogenin control region.

Mapping of myogenin transcription during embryogenesis using transgenes linked to the myogenin control region

During vertebrate embryogenesis, the muscle-specific helix-loop-helix protein myogenin is expressed in muscle cell precursors in the developing somite myotome and limb bud before muscle fiber formation and is further upregulated during myogenesis. We show that cis-acting DNA sequences within the 5' flanking region of the mouse myogenin gene are sufficient to direct appropriate temporal, spatial...

Unprocessed myogenin transcripts accumulate during mouse embryogenesis.

The gene myogenin encodes a helix-loop-helix protein whose function is critical to the integrity of the mammalian myogenic cascade. In vitro, the expression of this gene immediately precedes terminal differentiation, as measured by the synthesis of those proteins that make up the contractile apparatus. However, during mammalian development, expression of myogenin and the appearance of sarcomere...

MyoD and Myogenin

Myogenin Controls Muscle Metabolism

Streptomyces cell death, which occurs as the bacteria develop fruiting bodies and form spores, has been dismissed as nonspecific autolysis caused by cell wall degradation. Now Miguélez et al. (page 515) show that the cell death is complex: it occurs at two different times in two different locations and as a series of defined steps that leave the cell wall intact. Streptomyces grow first along a...

The Expression of Myogenin and Myostatin Genes in Baluchi Sheep

Myogenin gene (MYoG) affects the synthesis of muscle myofibrillar growth and increase of meat production. The myostatin (MSTN) gene is identified as a specific negative regulator of skeletal muscle growth. Reduction of the expression level of MSTN throughmutation in the sequence of this gene leads to an increase of myogenesis and regeneration of muscle cells during the postnatal growing period ...